组长简介

李春义

研究员        博士生导师        特种经济动物分子生物学省部共建国家重点实验室常务副主任

               国际著名鹿茸研究专家,中国农业科学院二级岗位杰出人才。曾任新西兰茵沃梅皇家农业科学院研究员(AgResearch Invermay Agricultural Centre)、项目主持人,现任特种经济动物分子生物学省部共建国家重点实验室(China)常务副主任及特种经济动物干细胞创新团队首席科学家。现主持国家863课题1项,973前期专项2项,国家自然科学基金2项,吉林省自然科学基金重点项目1项,吉林省科技发展计划1项。已培养研究生19名(含海外),其中博士生6名。

早在1982年于中国农业科学院特产所攻读硕士期间就涉足鹿茸研究领域,于1985年获得中国农业科学院动物生理学硕士学位,1997年获得新西兰Otago大学医学院生理学博士学位,毕业后受聘于新西兰皇家农业科学院(AgResearch NZ Ltd)进行更深层次鹿茸生物学研究,2006年至今就职于中国农业科学院特产研究所。从事鹿茸生物学研究30余年,共发表学术论文90余篇(SCI收录50余篇);参加相关的国际会议30余场;撰写专著4本。曾获得1990年中国科协颁发的“中国青年科技奖”;2002年吉林省和中国农业科学院“科学技术进步二等奖”(第一名);2003年“中国科学技术进步二等奖”(第三名);2003 年World Research Promotion Council 颁发的“杰出科学家奖”。

事业上的成就得到了国际同行们的广泛认可,应邀在第一届(2000年,加拿大Banff)、第二届(2004年,新西兰Queenstown)和第三届(2011年,中国长春)国际鹿茸科学及产品技术大会,以及第六届(2006年,捷克Prague)、第七届(2010年,智利Huilo Huilo)和第八届(2014年,中国哈尔滨)国际鹿生物学大会上作全会报告。多年坚实的研究工作取得了卓越成就,最大贡献是促进了鹿茸作为生物医学模型的发展,对鹿茸生物学的研究将对人类健康事业做出巨大的贡献;同时这些研究也为大幅度提高鹿茸产量奠定了基础。

           

主要论文【more】


  • 1.      Chunyi Li and Wenhui Chu (accepted) The regenerating antler blastema: the derivative of stem cells resident in a pedicle stump. Frontiers in Bioscience (Landmark Edition).

    2.      Guo Q, Wang D, Liu Z and Li Chunyi (2015) Effects of p21 Gene Down-Regulation through RNAi on Antler Stem Cells In Vitro. PLoS ONE 10(8): e0134268. doi:10.1371/journal.pone.0134268.

    3.      Haiping Zhao, Zhen Liu, Wenhui Chu and Chunyi Li (2015) Organ morphogenesis, bioelectricity and organ morphogenetic model in mammals -- deer antler. Animal Production Science. http://dx.doi.org/10.1071/AN14902.

    4.      Santanu Deb-Choudhury, Wenying Wang, Stefan Clerens, Chris McMahon, Jolon Dyer and Chunyi Li (2015) Direct localisation of molecules in tissue sections of growing antler tips using MALDI imaging. Mol Cell Biochem DOI 10.1007/s11010-015-2527-7.

    5.      Li Chunyi, Haiping Zhao, Zhen Liu and Chris McMahon (2014) Deer antler – A novel model for studying organ regeneration in mammals.  Int J Biochem Cell Biol. 56:111–122.

    6.      Hengxing Ba, Lang Wu, Zongyue Liu, and Chunyi Li (2014) An examination of the origin and evolution of additional tandem repeats in the mitochondrial DNA control region of Japanese sika deer (Cervus Nippon). ISSN: 1940-1736 (print), 1940-1744 (electronic).

    7.      Shao X, Y Wen, H Ba, X Zhang, Z Yue, K Wang, Chunyi Li, J Qiu, and F Yang (2014) Novel Amdoparvovirus Infecting Farmed Raccoon Dogs and Arctic Foxes. Emerging Infectious Diseases. DOI: http://dx.doi.org/10.3201/eid2012.140289.

    Wang S, Zheng J, Yang Y, Liu Z, Yu M, Li Chunyi and Yang F (2014) Fusion competence of interspecies nuclear transfer embryos reconstructed from pedicle periosteum cell of sika deer (Cervus nippon) and Oocyte of bovine.  Asian Journal of Animal Sciences. 8(3): 79-85.

  • Hengxing Ba, Fuhe Yang, Xiumei Xing, and Chunyi Li (2013) Classification and phylogeny of sika deer (Cervus nippon) subspecies based on the mitochondrial control region DNA sequence using an extended sample set. Mitochondrial DNA. ISSN: 1940-1736 (print), 1940-1744 (electronic).

  • Chunyi Li, Allan Pearson, and Chris McMahon (2013) Morphogenetic Mechanisms in the Cyclic Regeneration of Hair Follicles and Deer Antlers from Stem Cells. BioMed Research International. Volume 2013, Article ID 643601, 21pages.

  • Hongmei Sun, Fuhe Yang, Wenhui Chu, Haiping Zhao, Chris McMahon, Chunyi Li(2013) Lentiviral-Mediated RNAi Knockdown of Cbfa1 Gene Inhibits Endochondral Ossification of Antler Stem Cells in Micromass Culture. PLoS ONE 7(10): e47367.

  • Chunyi Li (2013) Histogenetic aspects of deer antler development. Front Biosci (Elite Ed). 5:479-89.

  • Chunyi Li (2012) Deer antler regeneration: a stem cell-based epimorphic process. Birth Defects Res C Embryo Today. 96(1):51-62

  • Chunyi Li, Anne Harper, Jonathan Puddick, Wenying Wang and Chris McMahon (2012) Proteomes and Signalling Pathways of Antler Stem Cells. PLoS ONE. 7(1): e30026. doi:10.1371/journal.pone.0030026

  • Gao Zhiguang, Fuhe Yang, Chris McMahon and Chunyi Li (2012) Mapping the morphogenetic potential of antler fields through deleting and transplanting subregions of antlerogenic periosteum in sika deer (Cervus nippon). Journal of Anatomy. 2012(2):131-143.

  • Chunyi Li, Jimmy Suttie (2012) Morphogenetic aspects of deer antler development. Frontiers in Bioscience. E4, 1836-1842.

  • Fuhe Yang Wenying Wang, Junde Li, Stephen Haines, Geoff Asher and Chunyi Li (2011)Antler development was inhibited or stimulated by cryosurgery to periosteum or skin in a central antlerogenic region respectively. J Exp Zool B Mol Dev Evol. 316:359–370.

  • Chunyi Li, Fuhe Yang and Jimmy Suttie (2011)Stem cells, stem cell niche and antler development. Animal Production Science. 51:267-276.

  • Xing Xiumei, Fuhe Yang and Chunyi Li (2011) Studies on Molecular Genetic Diversity of Chinese sika deer and wapiti. Animal Production Science. 51:301.

  • Li Chunyi (2010) Exploration of the Mechanism Underlying Neogenesis and Regeneration of Postnatal Mammalian Skin: Deer Antler Velvet. International Journal of Medical and Biological Frontiers. 16 (11/12): 89-99.

  • Li Chunyi, Fuhe Yang, Stephen Haines, Haiping Zhao, Wenying Wang, Xiumei Xing, Hongmei Sun, Wenhui Chu, Xiaoping Lu, Linling Liu, Chris McMahon (2010) Stem cells responsible for deer antler regeneration are unable to recapitulate the process of first antler development---Revealed through intradermal and subcutaneous tissue transplantation. J Exp Zool B Mol Dev Evol. 314:1-19.

  • Gao Xiuhua, Fuhe Yang, Haiping Zhao, Wenying Wang, Chunyi Li (2010) Antler transformation is advanced by inversion of antlerogenic periosteum implants in sika deer (Cervus nippon). Anat. Rec. 239:1787-1796.

  • Li Chunyi, Gao X, Yang F, et al. (2009). Development of a nude mouse model for the study of antlerogenesis - mechanism of tissue interactions and ossification pathway. J Exp Zool B Mol Dev Evol. 312(2):118-35.

  • Kierdorf U, Li Chunyi, Price JS (2009). Improbable appendages: Deer antler renewal as a unique case of mammalian regeneration. Seminars in cell & developmental biology. 20(4):535-542.

  • Li Chunyi, Fuhe Yang, Sheppard Allan (2009) Adult stem cells and mammalian epimorphic regeneration---Insights from studying annual renewal of deer antlers. Current Stem Cell Research & Therapy. 4:237-251.

  • Li Chunyi, Fuhe Yang, Xiumei Xing, Xiuhua Gao, Xuming Deng, Colin Mackintosh, and James M Suttie (2008). Role of heterotypic tissue interactions in deer pedicle and first antler formation---Revealed via a membrane insertion approach. J Exp Zool B Mol Dev Evol. 310B:267-277.

  • Li Chunyi, Fuhe Yang, Guangyu Li, Xiuhua Gao, Xiumei Xing Haijun Wei, Xuming Deng, and Dawn Clark (2007) Antler regeneration: A dependent process of stem tissue primed via interaction with its enveloping skin. Journal of Experimental Zoology. 307A:95–105.

  • Chunyi Li, Colin G. Mackintosh, Shirley K. Martin and Dawn E. Clark (2007) Identification of key tissue type for antler regeneration through pedicleperiosteum deletion. Cell and Tissue Research. 328:65–75.